Monica T. Dayao

Computational Biologist @ Biohub. Machine Learning for Biology. PhD in CompBio from CMU.

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Hi! I’m a computational biologist at Biohub and a member of the DeRisi Lab at UCSF. My current research is focused on developing and applying machine learning models to better understand autoimmune disease, specifically studying antibody-antigen interactions at scale.

Research Interests:
  • machine learning for biology
  • modeling antibody-antigen interactions
  • biology foundation models for patient-focused research
  • computer vision
Previously:

I did my PhD in the Systems Biology Group at Carnegie Mellon University, advised by Prof. Ziv Bar-Joseph. My thesis focused on developing machine learning methods for the analysis of spatial proteomics datasets, as part of the Human BioMolecular Atlas Program (HuBMAP). I collaborated closely with Enable Medicine and the University of Pittsburgh Medical Center (UPMC).

I earned my BA and MEng degrees in Engineering, with specializations in Information Engineering and Bioengineering, from the University of Cambridge. There, I worked with Dr. Timothy O’Leary and collaborated with Prof. Jim Haseloff on deep learning approaches for the segmentation of plant microscopy images.

Misc.

During my free time, I enjoy climbing, mountaineering, cooking/baking, cycling, golfing, and playing volleyball. My fiancé and I own a small camper van named Mochi, which we use for many of our outdoor adventures.

news

Nov 17, 2025 My paper “Using spatial proteomics to enhance cell type assignments in histology images” has been published in Cell Reports Methods. Check it out here.
Oct 7, 2024 I successfully defended my PhD thesis, “Machine learning methods for the analysis and modeling of highly multiplexed spatial proteomic data”. Thank you to everyone who supported me along this journey!
Aug 4, 2023 I received the “Best Oral Presentation” TransMed 2023 Award for my presentation at ISMB/ECCB 2023. Check out the CMU news article.
Jun 30, 2023 My ISMB/ECCB 2023 proceedings paper has been published in Bioinformatics. Check it out here!
Apr 11, 2023 My paper “Deriving spatial features from in situ proteomics imaging to enhance cancer survival analysis” has been accepted to the ISMB/ECCB 2023 proceedings!